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Methionine belongs to the twenty amino acid making up proteins. It is an essential sulfur-containing amino acid. As essential aminoacid, It cannot be synthesized by the animal and its requirement should be supplied trough the feed

It is one of the first limiting amino acids in the synthesis of any protein. It is also required for many cellular functions, such as:

Initiation of protein synthesis
Methylation of DNA and rRNA
Biosynthesis of cysteine
Synthesis of phospholipids and polyamines
Nowadays it is a common practice to include synthetic or analogous methionine in feed compound due to:

  • The continuous improvement in the animal genetically growth capacity of the last decades makes necessary a more concentrate nutrients feed. 

  • The elevate price and low availability of rich methionine raw materials. 

  • Natural variability of methionine content in raw materials. 

Brown chicken
The optimal level of methionine has been widely studied. Low levels produce immediately worsening of zootechnical parameters.

  • Reduced growth rate. 

  • Worsening FCR. 

  • Hepatic damage. 

  • Bad condition of immune system leading to higher susceptibility. 

  • Poor feathering. 

  • Decreased egg production and egg weight. 

Methionine should be balanced with the rest of essential aminoacids. Adding methionine when other essential aminoacids are limiting is of none or low benefit.

For example, in the case of adding methionine to a feed that is deficient in lysine, the protein synthesis will only continue to the level associated with the first limiting amino acid, in this case lysine.


Is a nutraceutical product that acts in feeds as adjuvant to methionine (from Latin, adiuvare: to aid). Adjuvant is a factor that helps in solving the health or nutritional problem in supplementary manner. METHPLUS administration makes stronger the effect of the methionine, allowing lower doses of the same with analogous effects. It allows to replace DL-methionine one to one up to 1 Kg.

METHPLUS is a European product manufactured under its quality standards.
METHPLUS fulfils the norms of traceability and guarantees homogeneity in composition and results.

Its main components are considered in European Union raw materials and flavoring and botanical defined additives. Plants extracts has been used in history for several uses, and have important activities related to health and nutrition. Algae and herbal meal, parts and extracts are on the base of METHPLUS that:

METHPLUS increases the digestibility
of raw materials and makes the methionine from the diet more
METHPLUS improves renal and hepatic activity
helps to keep plasmatic homocysteine (methionine precursor) on correct levels.
METHPLUS is a source of sulfur and several precursors of methionine
and methionine recyclers which take part in Methionine Salvage Pathway.

METHPLUS is an effective and profitable replacer of synthetic methionine which allows to substitute DL-Methionine (1 to 1 up to 1 Kg/Mt)

at much more competitive quotation and keeping the same animal performance (or even improving it!!).

METHPLUS is commercialized in the 5 continents and it has demonstrated its effectivity in very different scenarios considering climate, raw material avalibility, genetics, management and the different industrial conditions of each country.

METHPLUS® – product´s development was supported by European Union funds and 3 years long investigation program in collaboration with The Centre for Industrial Technological Development (2010 -2013, CDTI).
Friesian cow

METHPLUS has been designed to be used in monogastrics and aquaculture species.
METHPLUS VL specific for rumiants.



Disclaimer: The info contained within this web page is intended for international use and is for information only. Specific product details may vary from country to country, including among EU countries. Changes can affect to composition, indications of use, specifications, target species, but also product name and others.  Then product details of any particular product in any country should be checked with the information supplied by Liptosa in these country and specifically with the product labelling. In case of any question or doubt you can contact Liptosa in info@liptosa.com.

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